Hundreds of microbial genomes have been sketched out
Thousands of gene clusters have been identified, and new antibiotics may be created
Journal of science and technology Beijing, June 14 (xinhua Zhang Mengran) UK 14, published online in the journal nature of the latest achievements in a microbiology, scientists in the United States team mapped hundreds of cultivation and none of them has been studied microbial genome sequence, and identified more than one thousand biosynthesis gene cluster. Studies have shown that bacteria in the soil are likely to represent a new antibiotic to be developed, as well as a source of other medicinal compounds.
Bacteria have become more and more powerful in the game against antibiotics. Antibiotics is essentially microbes (including bacteria, fungi and actinomycetes) or higher animals and plants in the process of the life of a class of secondary metabolites, have the function of the resistance to pathogen or other activity, interferes with the development of other cellular functions. Scientists now believe new antibiotics are needed to stem the rise of drug-resistant infections. But in the past 30 years, only a very small number of new antibiotics have been developed, and new antibiotics are urgently needed to fight multidrug-resistant pathogens.
Researchers at the university of California, Berkeley, Julian in this field, and his colleagues, the successful produced hundreds of cultivation and basic has not been studied the microbial genome sequence, the microbes from northern California a prairie soil ecosystem. The team then identified more than a thousand biosynthetic gene clusters and speculated that they could synthesize a range of molecules, including peptides, antibacterial toxins and other metabolites with unknown functions. The expression of these genes varies with the depth and location of soil samples collected, reflecting their biological responses to different environmental conditions.
Known soil microbes can produce a variety of useful secondary metabolites, including antibiotic, antifungal agent and immune inhibitor, but most of them are all derived from the microbiota minority culture. Now the study has expanded the potential sources of these molecules and even found two previously unknown species of bacteria with unusually strong biosynthesis capabilities. The study also raised the possibility that soil microbes could communicate with each other using this complex chemical language.
Penicillin changed the world in the 1940s with the advent of antibiotics that allowed many formerly incurable diseases to be cured. But then the virus continues to evolve and develop resistance. It is believed that the only effective way is to make new antibiotics out - it needs a large number of related basic research to confirm the antibiotic of microbes, including check thousands of different samples, training, screening and determine its not old antibiotics. As a result, hundreds of unstudied, uncultured sketches of microbial genomes are seen as promising new antibiotics.